Biological plausibility for interactions between dietary fat, resveratrol, ACE2 and SARS-CoV illness severity.
Identifieur interne : 000965 ( 2020/Analysis ); précédent : 000964; suivant : 000966Biological plausibility for interactions between dietary fat, resveratrol, ACE2 and SARS-CoV illness severity.
Auteurs : Justine R. Horne [Canada] ; Marie-Claude Vohl [Canada]Source :
- American journal of physiology. Endocrinology and metabolism [ 1522-1555 ] ; 2020.
Abstract
The ACE2 cellular receptor is responsible for the pathogenesis of SARS-CoV, thus impacting the entrance and clearance of the virus. Studies demonstrate that upregulation of ACE2 has a protective effect on SARS-CoV-2 illness severity. Moreover, animal studies demonstrate that dietary intake can modulate ACE2 gene expression and function. A high intake of resveratrol may have a protective role, upregulating ACE2, whereas a high intake of dietary fat may have a detrimental role, downregulating ACE2. As such, we postulate on the biological plausibility of interactions between dietary fat and/or resveratrol and ACE2 gene variations in the modulation of SARS-CoV-2 illness severity. We call to action the research community to test this plausible interaction in a sample of human subjects.
DOI: 10.1152/ajpendo.00150.2020
PubMed: 32310688
Affiliations:
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pubmed:32310688Le document en format XML
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Horne</name><affiliation wicri:level="1"><nlm:affiliation>Centre Nutrition, Santé et Société (NUTRISS)-Institut sur la nutrition et les aliments fonctionnels (INAF), Université Laval, Quebec City, Quebec, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Centre Nutrition, Santé et Société (NUTRISS)-Institut sur la nutrition et les aliments fonctionnels (INAF), Université Laval, Quebec City, Quebec</wicri:regionArea><wicri:noRegion>Quebec</wicri:noRegion></affiliation></author><author><name sortKey="Vohl, Marie Claude" sort="Vohl, Marie Claude" uniqKey="Vohl M" first="Marie-Claude" last="Vohl">Marie-Claude Vohl</name><affiliation wicri:level="1"><nlm:affiliation>Centre Nutrition, Santé et Société (NUTRISS)-Institut sur la nutrition et les aliments fonctionnels (INAF), Université Laval, Quebec City, Quebec, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Centre Nutrition, Santé et Société (NUTRISS)-Institut sur la nutrition et les aliments fonctionnels (INAF), Université Laval, Quebec City, Quebec</wicri:regionArea><wicri:noRegion>Quebec</wicri:noRegion></affiliation></author></analytic><series><title level="j">American journal of physiology. Endocrinology and metabolism</title><idno type="eISSN">1522-1555</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The ACE2 cellular receptor is responsible for the pathogenesis of SARS-CoV, thus impacting the entrance and clearance of the virus. Studies demonstrate that upregulation of ACE2 has a protective effect on SARS-CoV-2 illness severity. Moreover, animal studies demonstrate that dietary intake can modulate ACE2 gene expression and function. A high intake of resveratrol may have a protective role, upregulating ACE2, whereas a high intake of dietary fat may have a detrimental role, downregulating ACE2. As such, we postulate on the biological plausibility of interactions between dietary fat and/or resveratrol and ACE2 gene variations in the modulation of SARS-CoV-2 illness severity. We call to action the research community to test this plausible interaction in a sample of human subjects.</div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><country name="Canada"><noRegion><name sortKey="Horne, Justine R" sort="Horne, Justine R" uniqKey="Horne J" first="Justine R" last="Horne">Justine R. Horne</name></noRegion><name sortKey="Vohl, Marie Claude" sort="Vohl, Marie Claude" uniqKey="Vohl M" first="Marie-Claude" last="Vohl">Marie-Claude Vohl</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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